Ph.D., University of California, Los Angeles, 2005
Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies
Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research.
Specifically, we are interested in:
• Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches.
• Re-engineering/re-wiring telomere regulatory pathways using synthetic biology modules and concepts.
• Chemical biology approach to identify small molecules that can inhibit telomere ON/OFF transition thereby inhibiting cancer cell progression.
Qiao, F., Song, H., Kim, C. A., Sawaya, M. R., Hunter, J. B., Gingery, M., Rebay, I., Courey, A. J., and Bowie, J. U., “Derepression by Depolymerization: Structural insights into the regulation of Yan by Mae”, Cell, 118:163-73 (2004)
Song, H., Nie, M., Qiao, F., Bowie, J. U., and Courey, A. J., “Antagonistic regulation of Yan nuclear export by Crm1 and Mae increases the stringency of the Ras response”, Genes & Development, 19: 1767-72 (2005)
Qiao, F. and Bowie, J. U., “The many faces of SAM”. Science Signaling, re7 (2005) [Cover of the issue]
Qiao, F., Harada, B., Song, H., Whitelegge, J., Courey A. J., and Bowie J. U., “Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site”, EMBO J, 25:70-9 (2006)
Harada, B. T., Knight, M. J., Imai, S., Qiao, F., Ramachander, R., Sawaya, M. R., Gingery M., Sakane, F., and Bowie, J. U., “Regulation of Enzyme Localization by Polymerization: Polymer Formation by the SAM Domain of Diacylglycerol Kinase δ1”, Structure, 16:380-7 (2008)
Qiao, F. and Cech, T. R., “Triple-helix structure in telomerase RNA contributes to catalysis”, Nature Structural & Molecular Biology, 15:634-40 (2008)
Qiao, F., Goodrich, K. J. and Cech, T. R., “Engineering cis-telomerase RNAs that add telomeric repeats to themselves”, Proc. Natl. Acad. Sci. [Direct submission] 107:4914-18 (2010)
Jun, H.I., Liu, J., Jeong, H., Kim, J.K., & Qiao, F., “Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.” Genes & Development, 27:1917-1931 (2013)