Feng Qiao

Ph.D., University of California, Los Angeles, 2005

Department of Biological Chemistry
University of California, Irvine
Irvine, CA 92697
(949) 824-0159 (Office), (949) 824-1013 (Lab)

UCI Faculty Profile: Feng Qiao

Feng Qiao

Research Interests:

Telomeres & telomerase and their roles in cancer and stem cell diseases; Structural, biochemical and molecular genetic analyses of nucleoprotein assemblies

Telomeres are closely involved in stem cell differentiation and cancer cell proliferation. Our long-term goal is to reveal new mechanisms for telomere length regulation and chromosome end protection. Therefore, valuable targets for mechanism-driven design of cancer and anti-aging therapeutics may be identified through our research.

Specifically, we are interested in:

• Regulation of telomere homeostasis from atomic level to system level using the integration of biochemistry, structural biology (especially, x-ray crystallography), and genetics approaches.

• Re-engineering/re-wiring telomere regulatory pathways using synthetic biology modules and concepts.

• Chemical biology approach to identify small molecules that can inhibit telomere ON/OFF transition thereby inhibiting cancer cell progression.

Selected Publications:

Qiao, F., Song, H., Kim, C. A., Sawaya, M. R., Hunter, J. B., Gingery, M., Rebay, I., Courey, A. J., and Bowie, J. U., “Derepression by Depolymerization: Structural insights into the regulation of Yan by Mae”, Cell, 118:163-73 (2004)

Song, H., Nie, M., Qiao, F., Bowie, J. U., and Courey, A. J., “Antagonistic regulation of Yan nuclear export by Crm1 and Mae increases the stringency of the Ras response”, Genes & Development, 19: 1767-72 (2005)

Qiao, F. and Bowie, J. U., “The many faces of SAM”. Science Signaling, re7 (2005) [Cover of the issue]                 
Qiao, F., Harada, B., Song, H., Whitelegge, J., Courey A. J., and Bowie J. U., “Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site”, EMBO J, 25:70-9 (2006)       

Harada, B. T., Knight, M. J., Imai, S., Qiao, F., Ramachander, R., Sawaya, M. R., Gingery M., Sakane, F., and Bowie, J. U., “Regulation of Enzyme Localization by Polymerization: Polymer Formation by the SAM Domain of Diacylglycerol Kinase δ1”, Structure, 16:380-7 (2008)

Qiao, F. and Cech, T. R., “Triple-helix structure in telomerase RNA contributes to catalysis”, Nature Structural & Molecular Biology, 15:634-40 (2008)

Qiao, F., Goodrich, K. J. and Cech, T. R., “Engineering cis-telomerase RNAs that add telomeric repeats to themselves”, Proc. Natl. Acad. Sci. [Direct submission] 107:4914-18 (2010)

Jun, H.I., Liu, J., Jeong, H., Kim, J.K., & Qiao, F., “Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.” Genes & Development, 27:1917-1931 (2013)


List of Publications via PubMed (NIH National Library of Medicine)